A newly published multicentre RCT demonstrates Smith+Nephew PICO single use NPWT as superior to traditional NPWT in reducing wound area, depth and volume in DFUs and VLUs

January 16, 2020
Business Wire

Smith+Nephew, the global medical technology business, is excited to announce the publication of results from a new randomised controlled trial demonstrating that the use of PICO◊ Single Use Negative Pressure Wound Therapy System significantly reduced wound area, depth and volume compared with traditional negative pressure wound therapy in patients with venous leg ulcers and diabetic foot ulcers.

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Beta-caryophyllene enhances wound healing through multiple routes

December 16, 2019
Plos One

Beta-caryophyllene is an odoriferous bicyclic sesquiterpene found in various herbs and spices. Recently, it was found that beta-caryophyllene is a ligand of the cannabinoid receptor 2 (CB2). Activation of CB2 will decrease pain, a major signal for inflammatory responses.

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Wound Healing Capacity, Antibacterial Activity, and GC-MS Analysis of Bienertia sinuspersici Leaves Extract

December 5, 2019
IOP Science

This study evaluates the wound healing efficacy of Bienertia sinuspersici leaves, a recently discovered species in the Arabian Gulf. A topical cream was formalized from the leaves and its wound healing activity was evaluated for incision, excision, and burn wound models. Bienertia sinuspersici extract was prepared and used for preliminary phytochemical screening, Gas Chromatography-MS analysis, antibacterial assay (disk diffusion method S. aureus, S. pyogenes, E. coli, and P. aeruginosa), antioxidant study, and to formulate a cream that was used for wound healing clinical trial.

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Patient’s Skin May Close Venous Ulcers

December 4, 2019
McKnight's Long-Term Care News

A pilot of a new cellular and tissue-based product derived from a patient’s own skin showed promise in closing venous stasis leg ulcers, even after conventional treatments had failed. Researchers treated 10 venous leg ulcer patients whose wounds remained open after at least a month of routine treatments with SkinTE, a first-of-its-kind product designed to regenerate full-thickness, functional skin that repairs and replaces a patient’s own.

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Patch Repair of Deep Wounds by Mobilized Fascia

November 27, 2019

Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their surrounding extracellular jelly-like matrix, including embedded blood vessels, macrophages and peripheral nerves, to form the provisional matrix.

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Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases: A double‐blinded placebo‐controlled study

October 11, 2019
International Wound Journal

Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long‐term treatment with AGE on cutaneous tissue perfusion.

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