This study evaluates the wound healing efficacy of Bienertia sinuspersici leaves, a recently discovered species in the Arabian Gulf. A topical cream was formalized from the leaves and its wound healing activity was evaluated for incision, excision, and burn wound models. Bienertia sinuspersici extract was prepared and used for preliminary phytochemical screening, Gas Chromatography-MS analysis, antibacterial assay (disk diffusion method S. aureus, S. pyogenes, E. coli, and P. aeruginosa), antioxidant study, and to formulate a cream that was used for wound healing clinical trial.
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Non-healing or slow healing chronic wounds are among serious complications of diabetes that eventually result in amputation of limbs and increased morbidities and mortalities. Chronic diabetic wounds show reduced blood vessel formation, inadequate cell proliferation and poor cell migration near wounds.
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A pilot of a new cellular and tissue-based product derived from a patient’s own skin showed promise in closing venous stasis leg ulcers, even after conventional treatments had failed. Researchers treated 10 venous leg ulcer patients whose wounds remained open after at least a month of routine treatments with SkinTE, a first-of-its-kind product designed to regenerate full-thickness, functional skin that repairs and replaces a patient’s own.
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Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their surrounding extracellular jelly-like matrix, including embedded blood vessels, macrophages and peripheral nerves, to form the provisional matrix.
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Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long‐term treatment with AGE on cutaneous tissue perfusion.
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This post hoc analysis evaluates the association between the frequency of diabetic foot ulcer (DFU) debridement and the proportion of ulcers treated with active continuous diffusion of oxygen (CDO) that heal in a 12-week evaluation period.
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A recent study found that being a smoker, having diabetes, and also having a history of coronary heart disease or stroke increases the lifetime risk for PAD by as much as five times that of someone of the same race, age, and sex who does not have those risk factors.
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Kerecis, the company pioneering the use of fish skin in tissue regeneration, today announced the results of a new prospective case study of Kerecis Omega3 Burn. The study, announced at the American Burn Association annual meeting, found that patients with partial-thickness burn and donor-site wounds healed quickly, with no infection, after treatment with the fish-skin graft.
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This study provides a review of the therapeutic potential of graphene dressing scaffolds and mesenchymal stem cells (MSCs) and their synergistic effects with respect to cutaneous wound healing. This study also considers their putative action mechanism based on the antibacterial, immunomodulating, angiogenic, matrix remodeling effects of materials belonging to the graphene family and MSCs during the wound healing process.
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The surgical procedure in skin‐tumor therapy usually results in cutaneous defects, and multidrug‐resistant bacterial infection could cause chronic wounds. Here, for the first time, an injectable self‐healing antibacterial bioactive polypeptide‐based hybrid nanosystem is developed for treating multidrug resistant infection, skin‐tumor therapy, and wound healing.
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