Wound Healing Capacity, Antibacterial Activity, and GC-MS Analysis of Bienertia sinuspersici Leaves Extract

December 5, 2019
IOP Science

This study evaluates the wound healing efficacy of Bienertia sinuspersici leaves, a recently discovered species in the Arabian Gulf. A topical cream was formalized from the leaves and its wound healing activity was evaluated for incision, excision, and burn wound models. Bienertia sinuspersici extract was prepared and used for preliminary phytochemical screening, Gas Chromatography-MS analysis, antibacterial assay (disk diffusion method S. aureus, S. pyogenes, E. coli, and P. aeruginosa), antioxidant study, and to formulate a cream that was used for wound healing clinical trial.

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Patient’s Skin May Close Venous Ulcers

December 4, 2019
McKnight's Long-Term Care News

A pilot of a new cellular and tissue-based product derived from a patient’s own skin showed promise in closing venous stasis leg ulcers, even after conventional treatments had failed. Researchers treated 10 venous leg ulcer patients whose wounds remained open after at least a month of routine treatments with SkinTE, a first-of-its-kind product designed to regenerate full-thickness, functional skin that repairs and replaces a patient’s own.

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Patch Repair of Deep Wounds by Mobilized Fascia

November 27, 2019

Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their surrounding extracellular jelly-like matrix, including embedded blood vessels, macrophages and peripheral nerves, to form the provisional matrix.

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Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases: A double‐blinded placebo‐controlled study

October 11, 2019
International Wound Journal

Laser Doppler velocimetry estimates tissue perfusion providing a record of microvascular blood flow. Patients with heart disease or diabetes mellitus have impaired microvascular perfusion leading to impaired wound healing. Aged garlic extract (AGE) has a positive effect on vascular elasticity. This study aimed to assess the effect of long‐term treatment with AGE on cutaneous tissue perfusion.

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Clinical Study Finds Burn Patients Treated with Kerecis® Omega3 Intact Fish Skin Experienced Pain Relief, Fast Healing and No Infections

April 17, 2019
PR Newswire

Kerecis, the company pioneering the use of fish skin in tissue regeneration, today announced the results of a new prospective case study of Kerecis Omega3 Burn. The study, announced at the American Burn Association annual meeting, found that patients with partial-thickness burn and donor-site wounds healed quickly, with no infection, after treatment with the fish-skin graft.

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The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism

April 17, 2019
Dove Press

This study provides a review of the therapeutic potential of graphene dressing scaffolds and mesenchymal stem cells (MSCs) and their synergistic effects with respect to cutaneous wound healing. This study also considers their putative action mechanism based on the antibacterial, immunomodulating, angiogenic, matrix remodeling effects of materials belonging to the graphene family and MSCs during the wound healing process.

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Injectable Self‐Healing Antibacterial Bioactive Polypeptide‐Based Hybrid Nanosystems for Efficiently Treating Multidrug Resistant Infection, Skin‐Tumor Therapy, and Enhancing Wound Healing

April 17, 2019
Wiley Online Library

The surgical procedure in skin‐tumor therapy usually results in cutaneous defects, and multidrug‐resistant bacterial infection could cause chronic wounds. Here, for the first time, an injectable self‐healing antibacterial bioactive polypeptide‐based hybrid nanosystem is developed for treating multidrug resistant infection, skin‐tumor therapy, and wound healing.

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