Monograph: Lower extremity arterial disease ulcers
Lower extremity arterial disease (LEAD) represents a later manifestation of peripheral arterial disease (PAD). LEAD is a spectrum of chronic limb symptoms caused by progressive narrowing and eventual occlusion of the arteries to the lower extremity. Arterial occlusion leads to ischemic tissue and eventual ulceration. Recent studies suggest that 8-12 million Americans have the condition and that for individuals 65 years or older the prevalence of LEAD is 12-20%.