Independent risk factors for pressure ulcer development in a high-risk nursing home population receiving evidence-based pressure ulcer prevention: Results from a study in 26 nursing homes in Belgium

November 13, 2018
Wiley Online Library

 

The aim of this study was to identify independent risk factors for pressure ulcer (PU) development in a high‐risk nursing home population receiving evidence‐based PU prevention. This study was part of a randomised controlled trial examining the (cost‐)effectiveness of static air support surfaces compared with alternating pressure air mattresses.

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Designing a novel cell-permeable peptide chimera to promote wound healin

November 13, 2018
Medical Xpress

Cell-penetrating peptides (CPPs) have attracted great interest as delivery vehicles in medicine, with potential for the development of novel therapeutic agents or cosmetic products. Biological membranes are typically impermeable to almost all compounds with a molecular weight greater than 500 Da.

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Fidgetin-Like 2 siRNA Enhances the Wound Healing Capability of a Surfactant Polymer Dressing

November 6, 2018
Mary Ann Liebert, Inc Publishers

Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are determined in large part by its regulatory proteins, including the recently discovered MT severing enzyme Fidgetin-like 2 (FL2).

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Harness the healing power of electricity

October 19, 2018
BMC

You may have experienced the disconcerting and uncomfortable sensation of an electric shock or even had an electroencephalogram (EEG) test, which monitors the electrical activity of the brain. The interaction between electricity and humans has become relatively commonplace, what’s less well known is that electrical signals also exist within humans.

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Probiotics and antibiotics create a killer combination

October 19, 2018
MIT News

In the fight against drug-resistant bacteria, MIT researchers have enlisted the help of beneficial bacteria known as probiotics. In a new study, the researchers showed that by delivering a combination of antibiotic drugs and probiotics, they could eradicate two strains of drug-resistant bacteria that often infect wounds.

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Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomized, controlled, double-blind phase 1/2 trial

October 8, 2018
The Lancet

Wound infections are the main cause of sepsis in patients with burns and increase burn-related morbidity and mortality. Bacteriophages, natural bacterial viruses, are being considered as an alternative therapy to treat infections caused by multidrug-resistant bacteria. We aimed to compare the efficacy and tolerability of a cocktail of lytic anti- Pseudomonas aeruginosa bacteriophages with standard of care for patients with burns.

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