Impact of Hyperbaric Oxygen on More Advanced Wagner Grades 3 and 4 Diabetic Foot Ulcers: Matching Therapy to Specific Wound Conditions

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Key Takeaways: 

  • Advanced modalities such as HBOT should not be evaluated as a “one size fits all” intervention. Instead, clinicians should identify the subset of patients most likely to benefit and align treatment intensity with wound severity. 
  • High‑acuity diabetic foot ulcers require a specialized infrastructure, pathway and coordination of care, and most hospitals underperform when treating these patients.  
  • HBOT can substantially improve healing outcomes in Wagner Grades 3 and 4 Diabetic ulcers when used appropriately and completed as prescribed 
  • Using a large observational dataset allowed for the study of outcomes in routine clinical practice rather than highly selected clinical trial populations.  
  • Reporting only overall healing rates can mask important differences between low-risk and high-risk wounds. 

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