Monograph: Radiation Induced Hemorrhagic Cystitis

Download

Monograph: Radiation Induced Hemorrhagic Cystitis

Radiation induced hemorrhagic cystitis (HC) can occur as early as 3 months after radiation or may not become evident for many years. Significant Grade 3-4 HC occurs in 3 – 8% of post pelvic radiation patients despite advances in administration technique and delivery. Historically, severe hemorrhagic cystitis was associated with a 44% mortality rate despite aggressive urinary diversion and cystectomy. Radiation causes chronic fibrosis, endarteritis and progressive tissue hypoxia of the bladder submucosa and muscular tissue with eventual scarring, mucosal sloughing and symptomatic hemorrhagic cystitis. Radiated tissue is rendered hypoxic, hypocellular, and hypovascular to the point that the tissue is no longer able to heal spontaneously resulting in recurrent symptomatic hematuria.

Go to Download

Monograph: The Clinical Case for Use of Hyperbaric Oxygen Therapy in the Treatment of Diabetic Wounds

Download

Monograph: The Clinical Case for Use of Hyperbaric Oxygen Therapy in the Treatment of Diabetic Wounds

Although diabetes can ravage the body in many ways, non-healing ulcers on the feet and lower legs are common outward manifestations of the disease. Also, diabetics often suffer from nerve damage in their feet and legs, allowing small wounds or irritations to develop unnoticed. Given the abnormalities of the microvasculature and other side effects of diabetes, these wounds take a long time to heal and require a specialized treatment approach for proper healing.

Go to Download